NMD Pharma Initiates a Combined Phase I/IIa Clinical Trial of NMD670 for the Treatment of Symptoms of Myasthenia Gravis
NMD Pharma A/S, a biotech company leading in the development of novel therapeutics for neuromuscular disorders, today announces that the first subject has been dosed in a Phase I/IIa clinical trial of NMD670, NMD Pharma’s lead program in development to treat the symptoms of myasthenia gravis (MG).
Aarhus, Denmark, 6 October 2020
NMD Pharma A/S, a biotech company leading in the development of novel therapeutics for neuromuscular disorders, today announces that the first subject has been dosed in a Phase I/IIa clinical trial of NMD670, NMD Pharma’s lead program in development to treat the symptoms of myasthenia gravis (MG). The trial is taking place at the Centre for Human Drug Research (CHDR) in Leiden, the Netherlands under the leadership of Dr Geert Jan Groeneveld, CHDR’s Chief Scientific Officer and Chief Medical Officer.
NMD670 is a first-in-class small molecule inhibitor of the muscle specific chloride ion channel, the ClC-1 ion channel. NMD Pharma has demonstrated that ClC-1 inhibition can strengthen neuromuscular transmission and ultimately skeletal muscle function and this novel treatment approach has demonstrated compelling preclinical safety and efficacy data for MG.
The combined Phase I/IIa clinical trial is a randomized, double-blind, placebo controlled, single and multiple dose escalation study designed to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of NMD670 in 79 male and female healthy subjects and patients with MG. The primary outcome includes a number of safety and tolerability endpoints and the secondary outcome, a number of pharmacokinetic endpoints.
Thomas Holm Pedersen, Chief Executive Office of NMD Pharma, said: “I am pleased to announce that our lead program has entered the clinic. NMD670 has already shown great promise in preclinical studies and we hope that these positive results will be replicated in humans. I would like to thank everyone at NMD for their hard-work and commitment in reaching this important milestone and we look forward to reviewing the top line data next year. ”Dr Geert Jan Groeneveld, Chief Scientific Officer and Chief Medical Officer at the CHDR and the Principal Investigator of the trial added: “It is a great privilege to lead this clinical study. Patients with myasthenia gravis suffer from muscle weakness which severely affects their quality of life. Current treatment options for this autoimmune condition are far from optimal so there is a great need to develop and evaluate new therapeutics such as NMD670. For this clinical trial, and in line with its innovative philosophy, CHDR has funded the development and validation of bespoke biomarkers to support the scientific objectives”
Contacts
NMD Pharma A/S
Thomas Holm Pedersen, CEO
E-mail: contact@nmdpharma.com
Consilium Strategic Communications
Mary-Jane Elliott / Ashley Tapp / Lindsey Neville
E-mail: NMDPharma@consilium-comms.com
Tel: +44 (0)20 3709 5700