Sucampo Acquires Vtesse Inc.

Strategic and Financial Benefits of the Transaction

Acquisition provides Sucampo with VTS-270, which is in a pivotal study for the treatment of Niemann-Pick Disease Type C1 (NPC-1)

Builds on Sucampo’s capabilities, global development platform and focus on specialized areas of high, unmet medical  need

Fully-enrolled global pivotal clinical trial, with results expected in mid-2018   Sucampo provides capabilities and resources to accelerate the global development and potential commercialization of  VTS-270

Aligns with Sucampo’s patient-focused mission and contributes to goal of building an increasingly diversified, global biopharmaceutical company

Product is expected to be launched and accretive to earnings beginning in 2019 Vtesse team will continue to support the advancement of VTS-270

About Niemann-Pick Disease Type  C1

Rare genetic disorder that begins impacting the lives of those affected from birth to early adulthood. Clinical symptoms do not slow or reverse, with complications from neurological manifestations being the primary cause of eventual fatalities

Incidence of NPC-1 is estimated between 1:100,000 to 1:150,000 live births Estimated 2,000-3,000 cases  globally

NPC-1 results in early death in the vast majority of cases Currently no approved treatments for the disease in the U.S.

About VTS-270

VTS-270 is a well-characterized mixture of 2-hydroxypropyl-ß-cyclodextrins (HPßCD) with   a specific compositional fingerprint that distinguishes it from other HPßCD mixtures. It is administered by an intrathecal infusion to directly address the neurological manifestations    of disease.   Preclinical and early clinical studies suggest that the administration of VTS-   270 may slow or stop certain indicators of NPC-1, an ultra-orphan, progressive and fatal disease caused by a defect in lipid transport within the cell.  VTS-270, which is currently in   a pivotal Phase 2b/3 trial, has been granted breakthrough therapy designation in the U.S. and orphan designation in both the U.S. and EU.  Effective treatment of NPC remains a   high unmet need, with no approved products for patients in the U.S.  Results from the  pivotal trial are expected in  mid-2018.

“We are extremely pleased to announce the acquisition of Vtesse. Sucampo brings significant capabilities to Vtesse and its program, and we believe that this acquisition not  only has the potential to make an important difference in the lives  of  patients,  their  families, and the dedicated physicians who care for them, but also to create value for shareholders. We welcome the employees of Vtesse to our team and look forward to accelerating the global development of VTS-270 in the hopes of bringing this novel  treatment to patients afflicted by Niemann-Pick Disease Type  C1 in the U.S. and around   the globe,” said Peter Greenleaf, Chairman and Chief Executive Officer of Sucampo.

“The Vtesse team remains fully committed to the NPC community and will  provide  continuity to the patients, families, and clinical sites in cooperation with Sucampo. We recognize that Sucampo shares our commitment to the patients and caregivers of NPC    and provides us with the best opportunity to bring this important treatment  to  NPC-1 patients in the U.S. and around the globe. Together, we will accelerate the global development and commercialization of VTS-270,  relying  on  the  complementary  capabilities at Sucampo. Our commitment to the  patients,  families  and  physicians  remains steadfast,” said Ben Machielse, Drs, President, Founder and Chief  Executive Officer of Vtesse Inc.

Since its launch in January 2015, the Vtesse team has fully enrolled the registrational     study of VTS-270 in NPC-1 at 20 clinical trial sites across  the  globe,  providing broad access for study-eligible patients. The team has also been developing a device to assist healthcare providers with administration of VTS-270 to patients, and has supported compassionate use of the drug  candidate.

Terms of the Transaction

Sucampo has acquired Vtesse for an upfront consideration of $200  million,  and  has  agreed to pay Vtesse shareholders contingent consideration based on mid-single digit to double-digit royalties on global net sales of the product based on increasing net sales   levels, and a share of net proceeds that may be generated from the monetization of the

pediatric review voucher, which is expected to be granted in connection with the approval   of the product in the U.S. The upfront payment was made in the form of issuance of 2,782,678 Sucampo Class A common shares to the Vtesse shareholders and the payment  of $170 million (subject to a working capital adjustment) in cash on hand. No external financing was required for this acquisition. The Vtesse shareholders have agreed to a three-month lock-up of the common shares that were issued, and Sucampo has agreed to register the common shares for resale after the lock-up expires.

Vtesse employees are expected to join Sucampo to continue the important mission they have embarked upon at Vtesse of bringing an NPC therapy to market.

Additionally, Vtesse and Sucampo intend to establish a foundation after the closing of the acquisition to support research related to NPC disease. The establishment of  this  foundation is a testament to the high level of commitment the Vtesse and Sucampo teams have to scientific advancement regarding NPC. Subject to finalizing the terms of the foundation, Vtesse’s equity holders have set aside a portion of the transaction proceeds to contribute to the foundation, and Sucampo intends to match the Vtesse shareholder contribution from its corporate  funds.

“At the time of Vtesse’s launch in January 2015, Vtesse’s original investors recognized the imperative of driving VTS-270 rapidly through clinical development to secure the data for regulatory approvals and to deliver the drug candidate  to  the  NPC-1  community. Sucampo is a global partner that is fully behind the original mission of Vtesse and its investment group. We’re very proud to join their shareholders in establishing a foundation that will support further research of and awareness-building for NPC disease,” said David Mott, General Partner, NEA, and Vtesse’s Board Chair.

Guidance

Sucampo today updated its guidance for the full year ending December 31, 2017, incorporating the Vtesse acquisition, as  follows:

Advisors

Jefferies LLC served as financial advisor to Sucampo and Leerink Partners served as financial advisor to Vtesse; Cooley LLP served as legal advisor to Sucampo, and Wilmer Cutler Pickering Hale and Dorr LLP served as legal advisor to Vtesse.

Non-GAAP  Financial Measures

This press release contains four financial metrics (Adjusted Net Income, EBITDA, Adjusted EBITA and Free Cash Flow) that are considered “non-GAAP” financial metrics under applicable Securities and Exchange Commission rules and regulations. These non- GAAP financial metrics should be considered supplemental to and not a substitute for financial information prepared in accordance with generally  accepted  accounting  principles. The company’s definition of these non-GAAP metrics may differ from similarly titled metrics used by others. Adjusted Net Income adjusts for specified items that can be highly variable or difficult to predict, and various non-cash items, which  includes  amortization of acquired intangibles, inventory step-up adjustment, R&D intangible asset impairment, restructuring costs, legal settlement,  acquisition  related  expenses,  amortization of debt financing costs, debt extinguishment, R&D license option expense, acquisition related acceleration of deferred revenue, foreign currency translations and the  tax impact of these adjustments. EBITDA reflects net income excluding the impact of provision for income taxes, interest expense, interest income, depreciation, R&D intangible asset impairment, amortization of acquired intangibles and inventory step-up adjustments. Adjusted EBITDA reflects EBITDA and adjusts for specified items that can be  highly  variable or difficult to predict, and various non-cash items, which includes share based compensation expense, restructuring costs, acquisition related expenses, debt extinguishment, R&D license option, legal settlement, foreign currency translations and the acquisition related acceleration of deferred revenue. Free cash flow reflects net cash provided by operating activities less expenditures made for property and equipment. The company views these non-GAAP financial metrics as a means to facilitate management’s financial and operational decision-making, including evaluation of the company’s historical operating results and comparison to competitors’ operating results. These non-GAAP financial metrics reflect an additional way of viewing aspects of the company’s operations that, when viewed with GAAP results may provide a more  complete  understanding  of factors and trends affecting the company’s business.

The determination of the amounts that are excluded from these  non-GAAP  financial  metrics is a matter of management judgment and depends upon, among other factors, the nature of the underlying expense or income amounts.  Because  non-GAAP  financial  metrics exclude the effect of items that will increase or decrease the company’s reported results of operations, management strongly encourages investors to review the company’s consolidated financial statements and publicly-filed reports in their entirety.

Company to Host Conference Call  Today

Sucampo will host a conference call and webcast today, Monday, April 3, 2017 at 8:30 am ET.   Conference call and Webcast participation details are as  follows:

Dial-in number: 888-636-8238 (domestic) or 484-747-6635 (international) Passcode: 98372393

Webcast  link: http://www.sucampo.com/investors/events-presentations/

Conference  call replay:

Dates: Starting at 11:30 AM ET, April 3, 2017 a replay of the teleconference and webcast will be available

Dial-in number: 855-859-2056 (domestic) or 404-537-3406 (international) Passcode: 98372393

Webcast link: http://www.sucampo.com/investors/events-presentations/; then click ‘Archived Events’

About Sucampo Pharmaceuticals,  Inc.

Sucampo Pharmaceuticals, Inc. is focused on the development and commercialization of medicines that meet major unmet medical needs of patients worldwide. Sucampo has two marketed products – AMITIZA, its lead product, and RESCULA – and a pipeline of product candidates in clinical development. A global company, Sucampo is headquartered in Rockville, Maryland, and has operations in Japan and Switzerland. For more information, please  visit www.sucampo.com.

The Sucampo logo and the tagline, The Science of Innovation, are registered trademarks    of Sucampo AG. AMITIZA is a registered trademark of Sucampo AG.

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About Vtesse Inc.

Vtesse Inc. is a rare disease company dedicated to developing drugs for patients suffering from underserved diseases. Vtesse closely collaborates with the National Institutes  of Health (NIH), parents, patient support groups and other academic institutions to advance VTS-270 towards regulatory approval. Vtesse is also progressing earlier stage programs    for lysosomal storage diseases, including next-generation therapeutics for NPC. Vtesse is based in Gaithersburg, Maryland. For more information, visit www.vtessepharma.com.

Forward-Looking Statement

This press release contains “forward-looking statements” as that term is defined in the Private Securities Litigation Reform Act of 1995. These include statements about the development and potential commercialization of VTS-270, the timing of expected clinical   trial results, the accretiveness of VTS-270 to earnings, if approved, and the timing of such accretiveness, the potential issuance of a pediatric review voucher and updated financial guidance. These statements are based on management’s  current  expectations  and  involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements may include statements regarding the development or commercial potential of Sucampo’s products, and other statements    that are not historical facts. The following factors, among others,  could  cause  actual  results to differ from those set forth in the forward-looking statements: the impact of pharmaceutical industry regulation and health care legislation; Sucampo’s ability to accurately predict future market conditions; Sucampo’s ability to successfully integrate the operations of acquired businesses; dependence on the  effectiveness  of  Sucampo’s  patents and other protections for innovative products; the effects of competitive products     on Sucampo’s products; and exposure to litigation and/or regulatory actions.

No forward-looking statement can be guaranteed and actual results may differ materially from those projected. Sucampo undertakes no obligation to publicly update any forward-

looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the  many uncertainties that affect Sucampo’s business, particularly those mentioned in the     risk factors and cautionary statements in Sucampo’s most recent Form 10-K as filed with   the Securities and Exchange Commission on March 8, 2017, as well as its filings with the Securities and Exchange Commission on Forms 8-K and 10-Q since the filing of the Form 10-K, all of which Sucampo incorporates by reference.

Contact:

Sucampo Pharmaceuticals, Inc. Silvia Taylor

Senior Vice President, Investor Relations and Corporate Affairs 1-240-223-3718

staylor@sucampo.com